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KMID : 0892920180270050377
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Experimental Neurobiology
2018 Volume.27 No. 5 p.377 ~ p.386
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Ubiquitin C-terminal Hydrolase L1 Regulates Lipid Raft-dependent Endocytosis
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Kang Seo-Jun
Kim Jin-Soo
Park Sang-Myun
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Abstract
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Ubiquitin C-terminal hydrolase L1 (UCH-L1) is a deubiquitinating enzyme that is highly expressed in neurons, and gathering evidence indicates that UCH-L1 may play pathogenic roles in many neurodegenerative disorders such as Alzheimer's disease and Parkinson's disease (PD). Additionally, lipid rafts have attracted interest in neurodegeneration as playing a common role in many neurodegenerative diseases. In the present study, we demonstrated that UCH-L1 associates with lipid rafts as with other PD-associated gene products. In addition, UCH-L1 regulates lipid raft-dependent endocytosis and it is not dependent on the expression and degradation of caveolin-1 or flotillin-1. Finally, UCH-L1 regulates cell-to-cell transmission of α-synuclein. This study provides evidence that many PD-associated gene products share common signaling pathways to explain the pathogenesis of PD.
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KEYWORD
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alpha-synuclein, UCH-L1, Parkinson's disease, prion disease
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